NEW ORLEANS Robert Griffin III began his NFL career by connecting on 19 of 26 passes for 320 yards and two touchdowns, and the Washington Redskins handed the Saints a 40-32 loss in their first game since the bounty scandal that overshadowed New Orleans' offseason.
Griffin completed his first eight passes, including an 88-yard touchdown pass to Pierre Garcon, tying for the second-longest scoring pass by a quarterback making his NFL debut.
Rookie running back Alfred Morris rushed for 96 yards and two touchdowns. Aldrick Robinson, making his NFL debut, had a touchdown catch among four receptions for 52 yards.
Drew Brees uncharacteristically struggled with accuracy, completing only 46 percent of his throws with two interceptions. But his 339 yards passing and three touchdowns kept the Saints in the game until his last desperate pass was picked off by Reed Doughty near the Redskins' goal line.
Bears 41, Colts 21
CHICAGO Jay Cutler threw for 333 yards and two touchdowns, and Michael Bush added a pair of scoring runs to spoil quarterback Andrew Luck's debut.
Brandon Marshall had nine catches for 119 yards and a touchdown in his first game since being reunited with Cutler, and Matt Forte ran for 80 yards and a score.
Luck finished his first NFL game 23 of 45 for 309 yards with a 4-yard touchdown pass to Donnie Avery early in the fourth quarter. He also was intercepted three times twice by Tim Jennings in an up-and-down effort as he stepped in for the departed Peyton Manning.
Reggie Wayne caught nine passes for 135 yards. But it was a familiar result for a team with new management and a new coach in Chuck Pagano.
Eagles 17, Browns 16
CLEVELAND Michael Vick overcame four interceptions by throwing a 4-yard touchdown pass to Clay Harbor with 1:18 left in the nerve-racking win.
Vick led the Eagles on a 91-yard scoring drive, capping it with his short toss to Harbor on his career-high 56th pass. Before Vick rallied his team, he played poorly and showed rustiness after playing just 12 snaps during preseason because of injuries.
Vick went 29 of 56 for 317 yards and two touchdowns.
Browns rookie quarterback Brandon Weeden threw four interceptions, the last to Kurt Coleman with 1:05 remaining.
Vikings 26, Jaguars 23, OT
MINNEAPOLIS Rookie Blair Walsh kicked four field goals, including a 55-yarder as regulation time expired and another one in overtime, and Adrian Peterson returned from a left knee injury to lift the Vikings.
Peterson ran 17 times for 84 yards and two touchdowns for the Vikings, who led for most of the second half until Blaine Gabbert's 39-yard touchdown heave with 20 seconds left in the fourth quarter put the Jaguars back in front.
For the first time since the NFL's new overtime scoring rule was installed last season, the first team on the board didn't immediately run off the field a winner.
After Walsh's 38-yard kick, the Vikings had to play defense again while the Jaguars had their chance to match. But Gabbert was hurried into a fourth-down overthrow, spoiling the debut for new Jaguars coach Mike Mularkey.
Lions 27, Rams 23
DETROIT Matthew Stafford threw a 5-yard touchdown pass to Kevin Smith with 10 seconds left.
Stafford made up for a shaky game by leading an 80-yard, nine-play, game-winning possession that included three passes of at least 18 yards.
Sam Bradford directed a go-ahead drive that set up Greg Zuerlein's 46-yard field goal and put the Rams ahead 23-20 with 1:55 left. But coach Jeff Fisher's debut ended with a loss because the Rams could not shut down Stafford in the end.
Stafford had three interceptions before halftime for the first time in his four seasons. Cortland Finnegan had a 31-yard interception return for a touchdown that gave the Rams a 13-7 lead late in the first half.
Jets 48, Bills 28
EAST RUTHERFORD, N.J. Mark Sanchez threw three touchdown passes, including two to rookie Stephen Hill, and the Jets eased concerns about their offense.
The Jets sprinkled in their wildcat package with Tim Tebow, who mostly was quiet but recovered a late onside kick by Buffalo, and Jeremy Kerley had a touchdown catch and a punt return for a score. Antonio Cromartie also took one of New York's three interceptions of Ryan Fitzpatrick to the end zone.
It was the most points the Jets have scored in a season opener. That's from a team that had many wondering what to expect after the first-team offense failed to score a touchdown in the first three games of the preseason.
Meanwhile, Mario Williams, the Bills' big free agent signing, was quiet as the Jets' offensive line protected Sanchez all game.
Texans 30, Dolphins 10
HOUSTON Arian Foster had two touchdown runs, Matt Schaub threw a touchdown pass to Andre Johnson, and Houston's defense dominated rookie Ryan Tannehill and Miami.
Tannehill threw three interceptions in a 6-minute stretch late in the first half, and the Texans opened impressively in what they believe can be a Super Bowl season.
Schaub threw for 266 yards in his first action since fracturing his right foot in Week 10 last year, and Johnson finished with 119 yards receiving. Texans defensive end J.J. Watt deflected two passes that resulted in interceptions and also had 1½ sacks.
Marcus Thigpen returned a punt 72 yards for Miami's touchdown. The Dolphins gained only 275 total yards in coach Joe Philbin's head coaching debut.
Patriots 34, Titans 13
NASHVILLE, Tenn. Tom Brady threw for 236 yards and two touchdowns, and the defending AFC champions won easily.
Brady may have suffered a broken nose when he was sacked in the second quarter by Kamerion Wimbley, but he didn't miss a play.
The Patriots ruined Jake Locker's debut as Tennessee's starter, sacking him twice and forcing two turnovers. Rookie Dont'a Hightower returned Locker's fumble 6 yards for a touchdown in his own debut, and Stevan Ridley ran for 125 yards and a touchdown.
Also, Locker came out of the game after hurting his left shoulder when tackling safety Patrick Chung on a fumble return. He was replaced by Matt Hasselbeck.
Falcons 40, Chiefs 24
KANSAS CITY, Mo. Matt Ryan threw for 299 yards and three touchdowns, one of them to Tony Gonzalez in his return to Kansas City.
Ryan also ran for a touchdown, while Julio Jones caught six passes for 108 yards and two scores.
The Falcons took advantage of a Chiefs defense missing four starters. Pro Bowl linebacker Tamba Hali was suspended for an unspecified violation of the league's substance-abuse policy, and three others were injured.
Kansas City matched Atlanta most of the first half, trailing 20-17 at the break. But a missed field goal by Ryan Succop early in the third quarter proved to be the turning point.
Matt Cassel finished with 258 yards passing for Kansas City, but also threw two interceptions and lost a fumble.
Arizona 20, Seattle 16
GLENDALE, Ariz. Kevin Kolb lost his job, then helped the Arizona Cardinals win their season opener.
Kolb replaced injured John Skelton and led Arizona on the deciding touchdown drive, throwing 6 yards to Andre Roberts for a score with 4:59 to play, and the Cardinals held on.
Aided by two pass interference penalties, Seattle drove to the Arizona 4-yard line in the final seconds. But rookie Russell Wilson threw three consecutive incompletions, and the Cardinals held on.
Adding to the confusion, Seattle appeared to have called a timeout when it had none remaining, but the replacement officials working the game later announced one of the previous timeouts was not, in fact, charged to the Seahawks.
Kolb, who lost out Skelton in the competition to start at quarterback for Arizona, was 6 of 8 for 66 yards on the winning drive.
Wilson, who won the quarterback job over Matt Flynn, completed 18 of 34 passes for 153 yards and a touchdown. He was intercepted once. Marshawn Lynch, questionable for the game after a sore back limited him in practice, carried 21 times for 85 yards.
49ers 30, Packers 22
GREEN BAY, Wis. San Franciscos defense smothered Aaron Rodgers and the Green Bay offense for most of the game, then made one last stand to stop a late rally.
Randall Cobb gave the Packers a chance with a 75-yard punt return for a touchdown, and a 2-point conversion cut the lead to 8 at 23-15 in the fourth quarter. But Rodgers threw an interception to linebacker NaVorro Bowman, and Frank Gore ran for a 23-yard touchdown.
Rodgers then threw a touchdown to James Jones, but the 49ers held the Packers in the final minute.
Things went so well for the 49ers that when David Akers tried a 63-yard field goal at the end of the first half, it bounced off the crossbar and then kept going through the uprights to tie an NFL record.
Rodgers finished 30 of 44 for 303 yards with two touchdowns and an interception, but the 49ers held him in check until late the in the game. Jermichael Finley had a 1-yard touchdown for the Packers.
Meanwhile, the Packers defense didnt look much better than last years porous unit. Alex Smith was 20 of 26 for 211 yards and two touchdowns while Gore rushed for 112 yards.
Buccaneers 16, Panthers 10
TAMPA, Fla. The Tampa Bay Buccaneers kept the heat on Cam Newton all day, leaving the Carolina star little room to throw the ball and even less to run.
A defense that allowed an NFL-worst 494 points and ranked last against the run last season intercepted Newton twice and limited the running game to 10 yards as the Bucs won their debut under coach Greg Schiano.
Josh Freeman threw a 6-yard touchdown pass to Mike Williams, and Connor Barth kicked three field goals to stop a 10-game losing streak that prompted the firing of former coach Raheem Morris. Schiano came to Tampa after spending 11 seasons transforming Rutgers from one of the worst programs in college football into a Big East contender.
Newton threw for 303 yards and one touchdown. But the Panthers were shut out in the first half, and the interceptions he threw thwarted Carolinas chances of overcoming the slow start.