A new study, which finds that immunity from the whooping-cough vaccine fades sharply through time, underscores the urgent need to develop new vaccines and consider additional booster shots for children, health experts say.
Authors say the study in the New England Journal of Medicine helps explain part of the resurgence in whooping cough, or pertussis, which has sickened more than 26,000 this year the largest outbreak in more than 50 years.
The current vaccine, in use since the 1990s, doesnt protect people as long as previously believed, losing 42 percent of its effectiveness with each passing year, says author Nicola Klein, co-director of the Kaiser Permanente Vaccine Study Center in Oakland, Calif. So even some fully vaccinated children who have received all five doses recommended by age 4 to 6 would still be vulnerable to the disease by age 10.
The Centers for Disease Control and Prevention has reached similar conclusions, says Tom Clark, a CDC epidemiologist specializing in whooping cough. While the whooping-cough vaccine protects about 98 percent of children in the first year, it protects only about 70 percent five years later, Clark says.
We know the short-term protection is very good, Clark says. But the protection is wearing off and that is the problem.
The findings shouldnt cause parents to stop vaccinating their children, however, Klein says. Even an imperfect vaccine is better than no vaccine, she says.
Whooping cough is typically more severe among unvaccinated children than among those whove had at least some of their shots, Clark says. Unvaccinated patients also tend to be sick longer and are often more contagious.
Doctors say theyre most concerned about infants.
Newborns too young to be fully vaccinated whose airways can quickly swell shut are the most likely to die from whooping cough, says C. Mary Healy, a pediatric infectious-disease specialist at Texas Childrens Hospital in Houston. Eleven of the 13 deaths from whooping cough this year were in infants; the other two deaths were in toddlers, according to the CDC.
Given the vaccines limitations, Healy says, its more important than ever to create a cocoon of protection around babies by vaccinating everyone around them. About 75 percent of babies with whooping cough contract the bacteria from a household member, such as a sibling, parent or grandparent.
If a vaccine does not have 100 percent protection thats lifelong, then its even more important that we have herd immunity to stop the virus from circulating into the community, Healy says. Thats an unacceptable level of infant deaths, in the 21st century, in the richest country in the world.
Ultimately, the country needs a better vaccine, says James Cherry of the University of California-Los Angeles.
But the business of coming up with a better vaccine is not going to be a quick fix, says Edgar Marcuse, a professor of pediatrics at Seattle Childrens Hospital. We still dont fully understand immunity from pertussis.
For example, even those naturally infected with whooping cough dont develop life-long immunity, and can come down with the bacterial infection again in 10 years or less, Marcuse says.
Infection rates today, in spite of the current outbreak, are 23 times lower than in the pre-vaccine days, Cherry says. In the pre-vaccine era, up to 270,000 Americans became sick with whooping cough each year, known as the 100-day cough, and up to 10,000 died, Klein says.
Vaccines, available beginning in the 1940s, cut infection rates dramatically. Whooping-cough rates began rising after the current vaccine, known as Dtap, came into widespread use in the late 1990s, Cherry says. Most of those reactions were mild, such as increased crying or sore arms and legs. Some children developed benign but frightening fever-related seizures, which occurred in about one in every 1,750 doses, says Gregory Poland, a professor of infectious disease at the Mayo Clinic in Minnesota.
An analysis by the Institute of Medicine found that DTP could cause rare but more serious problems: a dangerous brain inflammation, occurring in 1 to 10 per million doses; and an unusual, shock-like state, occurring 3 to 300 times per million doses, Poland says.
The experience with DTP had far-reaching effects.
Although multiple studies show that todays vaccines are safe, many parents remain nervous about immunizations, delaying or skipping some of their childrens shots a trend that has helped to fuel outbreaks of a number of infectious diseases, says Tom Belhorn, a pediatric infectious disease specialist at the University of North Carolina-Chapel Hill.
Until researchers produce a better vaccine with long-lasting immunity health experts could consider changing the vaccine schedule to get the most protection possible from the current shot, Poland says. Researchers would have to first carefully test the safety of any changes, he says, to avoid causing bad reactions.
For example, the CDCs Advisory Committee on Immunization Practices could consider adding an additional booster shot for teens who have made up a large number of whooping-cough patients at around 16 or 17, Clark says. Theres not much room in the current vaccine schedule to add extra shots for little kids, and there are currently no whooping-cough vaccines licensed for children ages 7 to 10.
To better protect infants, Cherry says, researchers could test the safety of giving babies their first three vaccinations by age 3 months, instead of 6 months. Vaccinating pregnant women also helps protect babies for the first month or two of life, he says.
© 2012 USA TODAY. All rights reserved.