Matt Schaub, Texans, threw for a career-high 527 yards and five touchdowns and completed a franchise-record 43 passes as Houston edged Jacksonville 43-37 in overtime.
Tom Brady, Patriots, had 331 yards passing and three touchdowns as New England routed the Indianapolis Colts 59-24.
Robert Griffin III, Redskins, threw four touchdown passes and ran for 84 yards in Washingtons 31-6 victory over Philadelphia.
Chad Henne, Jaguars, set a career high with four touchdown passes and threw for 354 yards in relief of an injured Blaine Gabbert as Jacksonville fell to Houston 43-37 in OT.
Peyton Manning, Broncos, threw three touchdown passes for the sixth time in seven games, leading Denver to its fifth consecutive win, 30-23 over San Diego. He also won his 148th regular-season game to tie John Elway for second on the career list for starting quarterbacks, and threw his 423rd TD pass to move into second in NFL history.
Doug Martin, Buccaneers, ran for 138 yards on 24 carries in Tampa Bays 27-21 victory at Carolina.
LaRod Stephens-Howling, Cardinals, rushed for 127 yards and a touchdown on 22 carries in a 23-19 loss at Atlanta.
Marcel Reece, Raiders, had 103 yards rushing on 19 attempts in Oaklands 38-17 loss to New Orleans.
Andre Johnson, Texans, caught 14 passes for 273 yards and a score in Houstons 43-37 overtime victory over Jacksonville.
Justin Blackmon, Jaguars, made seven catches for 236 yards and a TD as Jacksonville fell to Houston 43-37 in OT.
Dez Bryant, Cowboys, had 12 receptions for a career-high 145 yards and a touchdown in Dallas 23-20 overtime win over Cleveland.
Rob Gronkowski, Patriots, caught seven passes for 137 yards and two TDs giving him 10 scores, the first tight end in NFL history to have that many in three consecutive seasons, as New England routed Indianapolis 59-24.
Julian Edelman, Patriots, returned a punt 68 yards for a touchdown in New Englands 59-24 win over Indianapolis.
Nick Folk, Jets, kicked a pair of 51-yard field goals, becoming the second in franchise history with two kicks of at least 50 yards in the same game, helping New York top St. Louis 27-13.
Aqib Talib, Patriots, had a 59-yard interception return for a touchdown in his debut with New England, helping his new team to a 59-24 win over Indianapolis.
Von Miller, Broncos, had three sacks and two forced fumbles in Denvers 30-23 win over San Diego.
Jacksonvilles Blaine Gabbert left the Jaguars 43-37 overtime loss to the Houston Texans in the first quarter with a bruised right elbow. He was replaced by Chad Henne. ... Philadelphia running back LeSean McCoy left Philadelphias 31-6 loss to Washington in the fourth quarter with a concussion. McCoy was taken off the field on a cart after staying down following a 7-yard run with less than 2 minutes left. ... Kansas City wide receiver Dwayne Bowe left against Cincinnati with a neck injury, and left tackle Branden Albert left with a back injury. Also, Bengals cornerback Terence Newman was sidelined with a concussion. ... Atlanta cornerback Asante Samuel injured his right shoulder in the first quarter in the Falcons win over Arizona. ... Denver running back Willis McGahee hurt his right knee early in the second quarter when he was tackled by San Diego defensive back Quentin Jammer, and he did not return.
Quote of the Day
Im tired of talking about Robert. Nothings going to change; Roberts going to go out there and be special. Thats the gift that he has: Hes a special guy. He brings that kind of specialness. I dont know if thats a word, but he brings it to our offense, said Washingtons Santana Moss about teammate and rookie quarterback Robert Griffin III.