WASHINGTON The bacterial zoo inside your gut could look very different if youre a vegetarian or an Atkins dieter, a couch potato or an athlete, fat or thin.
Now for a fee $69 and up and a stool sample, the curious can find out just whats living in their intestines and take part in one of the hottest new fields in science.
Wait a minute: How many average Joes really want to pay for the privilege of mailing such, er, intimate samples to scientists?
A lot, hope the researchers running two novel citizen-science projects.
One, the American Gut Project, aims to enroll 10,000 people and a bunch of their dogs and cats too from around the country. The other, uBiome, separately aims to enroll nearly 2,000 people from anywhere in the world.
Were finally enabling people to realize the power and value of bacteria in our lives, said microbiologist Jack Gilbert of the University of Chicago and Argonne National Laboratory. Hes one of a team of well-known scientists involved with the American Gut Project.
Dont be squeamish: Yes, we share our bodies with trillions of microbes, living communities called microbiomes. Many of the bugs, especially those in the intestinal tract, play indispensable roles in keeping us healthy, from good digestion to a robust immune system.
But which combinations of bacteria seem to keep us healthy? Which ones might encourage problems like obesity, diabetes or irritable bowel syndrome?
And do diet and lifestyle affect those microbes in ways that we might control someday?
Answering those questions will require studying vast numbers of people. Getting started with a grass-roots movement makes sense, said National Institutes of Health microbiologist Lita Proctor, who isnt involved with the new projects but is watching closely.
After all, there was much interest in the taxpayer-funded Human Microbiome Project, which last summer provided the first glimpse of what makes up a healthy bacterial community in a few hundred volunteers.
Proctor, who coordinated that project, had worried there would be a real ick factor. That has not been the case, she said. Many people want to engage in improving their health.
Scott Jackisch, a computer consultant in Oakland, Calif., ran across American Gut while exploring the science behind different diets, and signed up last week. Hes read with fascination earlier microbiome research: Most of the genetic matter in what we consider ourselves is not human, and thats crazy. I wanted to learn about that.
Testing a single stool sample costs $99 in that project, but he picked a three-sample deal for $260 to compare his own bacterial makeup after eating various foods.
I want to be extra, extra well, said Jackisch, 42. Differing gut microbes may be the reason theres no one magic bullet of diet that people can eat and be healthy.
Its clear that peoples gut bacteria can change during time. What this new research could accomplish is a first look at how different diets may play a role, a much better understanding of what matters and what doesnt, said American Gut lead researcher Rob Knight of the University of Colorado, Boulder.
We dont just want people that have a gut-ache. We want couch potatoes. We want babies. We want vegans. We want athletes. We want anybody and everybody because we need that complete diversity, said American Gut co-founder Jeff Leach, an anthropologist.
One challenge is making sure participants dont expect that a map of their gut bacteria can predict their future health, or suggest lifestyle changes, anytime soon.
I understand Im not going to be able to say, Oh, my gosh, Ill be susceptible to this, said Bradley Heinz, 26, a financial consultant in San Francisco. He is paying uBiome $119 to analyze both his gut and mouth microbiomes; just the gut is $69.
The more people that participate, the more information comes out and the more that everybody benefits, he said.
Participants can sign up for either project through the social fundraising site Indiegogo.com during the next month. They also can send scrapings from the skin, mouth and other sites, to analyze that bacteria. Sign up enough family members or body sites, or be tracked through time, and the price can rise into the thousands. American Gut researchers plan some free testing for those who cant afford the fees, to increase the experiments diversity.
Dont forget the pets: We sleep with them, play with them, they often eat our food, Leach said. What bacteria we have in common is the next logical question.
Already, American Gut researchers are preparing to compare what they find in the typical U.S. gut with a few hundred people in rural Namibia, who eat whats described as hunter-gatherer fare. Also, Leach will spend three months living in Namibia next year, and is storing his own stool samples for before-and-after comparison.
But diet isnt the only factor. Your bacterial makeup starts at birth: Babies absorb different microbes when theyre born vaginally than when theyre born by C-section, a possible explanation for why cesareans raise the risk for certain infections. Taking antibiotics alters this teeming inner world, and its not clear if there are lasting consequences, especially for young children.
Then theres your environment, such as the infections spread in hospitals. In February, a new University of Chicago hospital building opens and Gilbert will test the surfaces, the patients and their health workers to see how quickly bad bugs can move in and identify which bacteria are protective.
Whatever the findings, all the research marks a huge teachable moment about how we interact with microbes, Leach said.